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Cannabidiol modulates excitatory-inhibitory ratio to counter hippocampal hyperactivity

Rosenberg et al. reveal a potential mechanism by which cannabidiol (CBD) reduces seizures. They discover that CBD restores the hippocampal excitatory-to- inhibitory ratio by preventing the actions of the lipid LPI at the receptor GPR55. Seizures acutely potentiate the GPR55- LPI axis, providing a target for CBD’s anti- seizure action.

The post Cannabidiol modulates excitatory-inhibitory ratio to counter hippocampal hyperactivity appeared first on Society of Cannabis Clinicians.

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